Megaloblastic anaemia of pregnancy and the puerperium.

نویسندگان

  • J W FORSHAW
  • A T JONES
  • W N CHISHOLM
  • W K MCGINLEY
چکیده

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An account of 335 cases of megaloblastic anaemia of pregnancy and the puerperium.

The incidence of megaloblastic anaemia in pregnancy and the puerperium in north Staffordshire has steadily declined as a result of prophylaxis with folic acid. In the presence of advanced folic acid deficiency and with a florid megaloblastic marrow, the anaemia is usually severe, but in many patients the disease is relatively mild and the degree of anaemia is determined more by blood loss or as...

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Enzymatic release of folate activity from the red cells in megaloblastic anaemia of pregnancy.

The content of folate activity precursors in washed red cells and the enzymatic plasma factor activity, necessary for the release of folate from the precursors, were studied in normal subjects and in patients with megaloblastic anaemia of pregnancy. Subjects with megaloblastic anaemia of pregnancy had a significantly reduced folate activity precursor content, and 14 subjects (58%) had significa...

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The absorption of vitamin B12 in megaloblastic anaemia associated with pregnancy.

The absorption of (60)CoB(12) has been studied in a group of patients suffering from megaloblastic anaemia associated with pregnancy and in a control group. The mean urinary excretion of (60)CoB(12) in the patients with megaloblastic anaemia is not significantly different from that of the control group. Five of the 30 patients showed a value towards the lower limit of normal, but the serum vita...

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Folic Acid and Vitamin B12 Levels in Pregnancy and Their Relation to Megaloblastic Anaemia.

There is a significant fall in the serum folic acid level during pregnancy, reaching its lowest level at term. This is most pronounced in twin pregnancies. A similar but less spectacular fall occurs in the vitamin B(12) concentration. In megaloblastic anaemia both folic acid and vitamin B(12) levels are lower than in other pregnant women. The degree of megaloblastic change in the bone marrow, a...

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Urinary formiminoglutamic acid in the megaloblastic anaemias associated with pregnancy and malnutrition.

The pathogenesis of many of the common forms of megaloblastic anaemia in malnourished populations is obscure. The aetiological factors and response to therapy vary in different geographical areas, and confusion has arisen by the retention of certain ambiguous terms. Thus "nutritional megaloblastic anaemia" is often really megaloblastic anaemia associated with pregnancy, and "tropical megaloblas...

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عنوان ژورنال:
  • American journal of obstetrics and gynecology

دوره 70 6  شماره 

صفحات  -

تاریخ انتشار 1942